Name: Melanotan 2
Brand: Au Peptide Labs (APL)
Price: 78.99 AUD
Availability: InStock

Overview

Melanotan 2 is a melanocortin receptor analog studied in MC receptor subtype-selectivity and downstream signalling assays.

Research Background

In research literature, Melanotan 2 is generally treated as a melanocortin receptor analog studied in MC receptor subtype-selectivity and downstream signalling assays. The melanocortin receptor family comprises five subtypes (MC1R–MC5R), all class A GPCRs primarily coupling via Gs to adenylyl cyclase. Melanotan I (afamelanotide) is a 13-amino acid [Nle⁴,D-Phe⁷]-α-MSH analog with preferential MC1R selectivity in binding assays. Melanotan II is a cyclic α-MSH analog (Ac-Nle⁴-c[Asp⁵,D-Phe⁷,Lys¹⁰]-α-MSH) with broader selectivity across MC1R, MC3R, MC4R, and MC5R. PT-141 (bremelanotide) is a metabolite of MT-II lacking the N-terminal acetyl and C-terminal amide, which preserves MC3R and MC4R agonism relevant to CNS-focused neuroendocrine assay models while reducing some peripheral receptor activity versus its parent compound.

The five MCR subtypes show distinct tissue distributions and ligand preferences, making receptor-subtype selectivity a central question when designing assay panels. Comparing MT-I, MT-II, and PT-141 in parallel using subtype-selective antagonists (e.g., SHU-9119 at MC3/4R, AGRP at MC3/4R) allows attribution of cAMP responses to individual receptor populations. For laboratory teams, the practical emphasis is usually on sequence identity, receptor or pathway relevance where documented, and whether Melanotan 2 behaves consistently across stability, purity, and analytical verification workflows. Variant labels on this page support clearer internal referencing when multiple labelled variants are under review.

Potential Research Applications

Potential research applications for Melanotan 2 should be framed strictly in analytical and laboratory terms. Typical reasons a team might review this product page include:

MC receptor subtype selectivity assays — MC1R-dominant (MT-I), versus mixed MC1/3/4/5R (MT-II), versus MC3/4R-enriched (PT-141) — in heterologous expression systems.

Gs-cAMP dose-response and Emax comparisons across the MT-I/MT-II/PT-141 series to map structure-activity relationships.

Pigmentation pathway studies in melanocyte or MC1R-expressing cell models using MT-I as the reference MC1R agonist.

MC4R-focused neuroendocrine assays using PT-141 as a selective CNS-relevant agonist reference.

Laboratory Handling & Storage

Handling decisions should always follow the vial label, internal SOPs, and any product-specific documentation. A conservative laboratory baseline for Melanotan 2 is:

Store sealed at –20 °C; cyclic disulfide or lactam bridges in these analogs are sensitive to reducing agents — avoid DTT or β-mercaptoethanol in preparation buffers.

Reconstitute in sterile water or physiological saline; avoid DMSO as co-solvent unless validated for the specific receptor assay format.

Maintain separate, clearly labelled stocks for MT-I, MT-II, and PT-141 — misidentification in an MCR selectivity panel would invalidate subtype attribution.

Confirm identity, purity, and correct cyclic structure against COA mass spectrometry data before receptor binding or cAMP assays.

Certificate of Analysis (COA)

A product-specific COA is linked on this page, with purity noted as 99.942%. The COA section is useful for confirming how the product is labelled in the catalogue, whether purity information has been published, and whether the laboratory record for the material is complete before bench use.

When teams compare Melanotan 2 with Melanotan 1, GHRP-2, and GHK-CU, COA access also helps keep comparator decisions grounded in documented material identity rather than assumption. That is especially important for research pages that combine pricing, variant selection, and analytical records on a single URL.

Certificate of Analysis

Verified purity: 99.942%

View COA

Frequently Asked Questions

What does this Melanotan 2 page cover?

It brings together 1 labelled variant: 10mg, current pricing context, stock visibility, COA access, and internal links to related catalogue pages so a laboratory buyer can review the material from a single reference URL.

How is Melanotan 2 usually positioned in research discussions?

Melanotan 2 is generally discussed as a melanocortin receptor analog studied in MC receptor subtype-selectivity and downstream signalling assays. The most relevant background is sequence behaviour, pathway or receptor context where documented, and analytical consistency under controlled laboratory conditions.

How should Melanotan 2 be handled after receipt?

Use the label, COA, and internal SOPs as the primary guide. In general, store the material under controlled laboratory conditions, minimise avoidable environmental exposure, and keep variant tracking records current.

Is Melanotan 2 accompanied by a certificate of analysis?

Yes. This listing includes access to a product-specific COA, which should be reviewed before use so purity, identity, and documentation checks are aligned with the project record.

Is Melanotan 2 sold for human or veterinary use?

No. The page should be interpreted strictly in a research and laboratory context. It does not provide dosage guidance, treatment claims, or human or animal use instructions.

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Melanotan 2