Format
Sealed research vial
Trust signal
COA-backed inventory
99%+ Purity
Lab-grade supply. Limited AU stock.
A$269
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Fast AU dispatch, tracked delivery, and documentation-ready inventory.
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High purity, consistent supply, and fast AU-wide dispatch.
Certificate of Analysis
COA library
Browse the current COA library and available product documentation.
SNAP-8 is an octapeptide analog of the N-terminal domain of SNAP-25 (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NHâ‚‚) studied as a competitive inhibitor of SNARE complex assembly in neuroendocrine secretion assay models.
SNAP-8 is frequently contrasted with botulinum neurotoxin serotype A (BoNT/A) in SNARE research because both reduce neuromuscular transmission but via mechanistically distinct routes — competitive binding versus proteolytic cleavage. This contrast is informative for assay designs examining SNARE complex reversibility and vesicle recycling.
Browse Inventory
In research literature, SNAP-8 is generally treated as an octapeptide analog of the N-terminal domain of SNAP-25 (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂) studied as a competitive inhibitor of SNARE complex assembly in neuroendocrine secretion assay models. SNAP-25 is a core member of the SNARE (soluble NSF attachment protein receptor) complex — alongside syntaxin-1A and VAMP-2 — that drives neurotransmitter vesicle fusion at the presynaptic membrane. SNAP-8 is a truncated octapeptide corresponding to the N-terminal region of SNAP-25 and competitively inhibits SNARE complex formation by occupying the binding interface before the full ternary complex assembles. In neuroendocrine cell models (e.g., PC12 cells or primary neuronal cultures), SNAP-8 reduces catecholamine vesicle exocytosis in a concentration-dependent manner, validated by catecholamine release assays (amperometry, ELISA). This mechanism makes SNAP-8 a research tool for studying vesicle fusion kinetics and SNARE inhibition specificity versus botulinum toxin-based SNAP-25 cleavage.
SNAP-8 is frequently contrasted with botulinum neurotoxin serotype A (BoNT/A) in SNARE research because both reduce neuromuscular transmission but via mechanistically distinct routes — competitive binding versus proteolytic cleavage. This contrast is informative for assay designs examining SNARE complex reversibility and vesicle recycling. For laboratory teams, the practical emphasis is usually on sequence identity, receptor or pathway relevance where documented, and whether SNAP-8 behaves consistently across stability, purity, and analytical verification workflows. Variant labels on this page support clearer internal referencing when multiple labelled variants are under review.
Potential research applications for SNAP-8 should be framed strictly in analytical and laboratory terms. Typical reasons a team might review this product page include:
Handling decisions should always follow the vial label, internal SOPs, and any product-specific documentation. A conservative laboratory baseline for SNAP-8 is:
If a product-specific file is not attached to this listing, the wider COA library remains the correct reference point for current published documentation. The COA section is useful for confirming how the product is labelled in the catalogue, whether purity information has been published, and whether the laboratory record for the material is complete before bench use.
When teams compare SNAP-8 with Glow, Klow, and NAD+, COA access also helps keep comparator decisions grounded in documented material identity rather than assumption. That is especially important for research pages that combine pricing, variant selection, and analytical records on a single URL.
Certificate of Analysis
COA library
Browse the current COA library and available product documentation.
It brings together 1 labelled variant: 10mg, current pricing context, stock visibility, COA access, and internal links to related catalogue pages so a laboratory buyer can review the material from a single reference URL.
SNAP-8 is generally discussed as an octapeptide analog of the N-terminal domain of SNAP-25 (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NHâ‚‚) studied as a competitive inhibitor of SNARE complex assembly in neuroendocrine secretion assay models. The most relevant background is sequence behaviour, pathway or receptor context where documented, and analytical consistency under controlled laboratory conditions.
Use the label, COA, and internal SOPs as the primary guide. In general, store the material under controlled laboratory conditions, minimise avoidable environmental exposure, and keep variant tracking records current.
This page links the broader COA library when a product-specific document is not attached. Laboratories should use the published documentation set that is currently available for the listing.
No. The page should be interpreted strictly in a research and laboratory context. It does not provide dosage guidance, treatment claims, or human or animal use instructions.
