Name: MOTS-c
Brand: Au Peptide Labs (APL)
Price: 94.99 AUD
Availability: InStock

Overview

MOTS-c is a 16-amino acid mitochondria-derived peptide (MOTS-c) encoded by the 12S rRNA gene of the mitochondrial genome and studied in AMPK activation and glucose metabolism assay models.

Research Background

In research literature, MOTS-c is generally treated as a 16-amino acid mitochondria-derived peptide (MOTS-c) encoded by the 12S rRNA gene of the mitochondrial genome and studied in AMPK activation and glucose metabolism assay models. MOTS-c is generated from a short open reading frame within human mitochondrial 12S rRNA (m.1382–1429), making it one of a small class of mitochondria-derived peptides (MDPs). In cell-based assays it activates AMPK (AMP-activated protein kinase) — a master metabolic sensor — partly via disruption of the methionine-folate one-carbon cycle and consequent effects on cellular AMP:ATP ratio. AMPK activation promotes GLUT4 translocation in skeletal muscle cell models and modulates fatty acid oxidation transcriptional programs. MOTS-c also translocates to the nucleus under stress conditions and has been studied as a transcriptional regulator of ARE (antioxidant response element)-containing gene networks.

Because MOTS-c originates from a mitochondrial genome open reading frame rather than a nuclear gene, it represents an unusual retrograde signalling axis from mitochondria to cytoplasm and nucleus. Research applications include mitochondrial-nuclear communication studies, AMPK pathway biology, and comparative work against synthetic AMPK activators (AICAR, metformin) in metabolic assay panels. For laboratory teams, the practical emphasis is usually on sequence identity, receptor or pathway relevance where documented, and whether MOTS-c behaves consistently across stability, purity, and analytical verification workflows. Variant labels on this page support clearer internal referencing when multiple labelled variants are under review.

Potential Research Applications

Potential research applications for MOTS-c should be framed strictly in analytical and laboratory terms. Typical reasons a team might review this product page include:

AMPK activation assays in skeletal muscle cell models measuring AMPK phosphorylation (Thr172) and downstream ACC phosphorylation.

GLUT4 translocation studies in differentiated myotube models comparing MOTS-c stimulation against insulin and AICAR controls.

One-carbon metabolism pathway studies examining MOTS-c-induced changes in SAM:SAH ratio and methylation status.

ARE-reporter gene assays studying MOTS-c nuclear translocation and antioxidant gene network activation.

Laboratory Handling & Storage

Handling decisions should always follow the vial label, internal SOPs, and any product-specific documentation. A conservative laboratory baseline for MOTS-c is:

Store at –20 °C sealed; MOTS-c is a small peptide and relatively stable as lyophilisate, but aqueous stock solutions should be aliquoted and stored at –80 °C for extended use.

Reconstitute in sterile PBS or water; the peptide is hydrophilic and dissolves readily at neutral pH.

Include matched peptide-sequence scramble controls in AMPK assay designs to confirm sequence-specific activity versus non-specific peptide effects.

Confirm purity and molecular weight against COA (MW ≈ 2174 Da) before functional assays.

Certificate of Analysis (COA)

A product-specific COA is linked on this page, with purity noted as available in the document. The COA section is useful for confirming how the product is labelled in the catalogue, whether purity information has been published, and whether the laboratory record for the material is complete before bench use.

When teams compare MOTS-c with TB-500, AOD-9604, and Semax, COA access also helps keep comparator decisions grounded in documented material identity rather than assumption. That is especially important for research pages that combine pricing, variant selection, and analytical records on a single URL.

Certificate of Analysis

Verified purity: Available in document

View COA

Frequently Asked Questions

What does this MOTS-c page cover?

It brings together 4 labelled variants: 20mg, 40mg, 5mg, and 10mg, current pricing context, stock visibility, COA access, and internal links to related catalogue pages so a laboratory buyer can review the material from a single reference URL.

How is MOTS-c usually positioned in research discussions?

MOTS-c is generally discussed as a 16-amino acid mitochondria-derived peptide (MOTS-c) encoded by the 12S rRNA gene of the mitochondrial genome and studied in AMPK activation and glucose metabolism assay models. The most relevant background is sequence behaviour, pathway or receptor context where documented, and analytical consistency under controlled laboratory conditions.

How should MOTS-c be handled after receipt?

Use the label, COA, and internal SOPs as the primary guide. In general, store the material under controlled laboratory conditions, minimise avoidable environmental exposure, and keep variant tracking records current.

Is MOTS-c accompanied by a certificate of analysis?

Yes. This listing includes access to a product-specific COA, which should be reviewed before use so purity, identity, and documentation checks are aligned with the project record.

Is MOTS-c sold for human or veterinary use?

No. The page should be interpreted strictly in a research and laboratory context. It does not provide dosage guidance, treatment claims, or human or animal use instructions.

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MOTS-c